The Real PURPOSE of PrEP — Effectiveness, Not Efficacy
Authors: Rochelle P. Walensky, M.D., M.P.H., and Lindsey R. Baden, M.D.Author Info & Affiliations
Published July 24, 2024
N Engl J Med 2024;391:1246-1247
DOI: 10.1056/NEJMe2408591
Abstract
Given the 40 years of research and the wealth of successful tools that have been developed to prevent, diagnose, treat, and suppress human immunodeficiency virus (HIV) infection, how is it possible that in 2024 the incidence of HIV type 1 (HIV-1) infection is more than 3.5 per 100 person-years among young women in southern Africa?1 The efficacy of preexposure prophylaxis (PrEP) to prevent HIV infection was first shown in 2010 in the landmark Preexposure Prophylaxis Initiative (iPrEx) trial of emtricitabine–tenofovir disoproxil fumarate (F/TDF), largely in men who have sex with men (MSM).2
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